Palytoxin-induced cell death cascade in bovine aortic endothelial cells
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چکیده
منابع مشابه
Palytoxin-induced cell death cascade in bovine aortic endothelial cells.
The plasmalemmal Na(+)-K(+)-ATPase (NKA) pump is the receptor for the potent marine toxin palytoxin (PTX). PTX binds to the NKA and converts the pump into a monovalent cation channel that exhibits a slight permeability to Ca(2+). However, the ability of PTX to directly increase cytosolic free Ca(2+) concentration ([Ca(2+)](i)) via Na(+) pump channels and to initiate Ca(2+) overload-induced onco...
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The maitotoxin (MTX)-induced cell death cascade in bovine aortic endothelial cells (BAECs), a model for Ca(2+) overload-induced toxicity, reflects three sequential changes in plasmalemmal permeability. MTX initially activates Ca(2+)-permeable, nonselective cation channels (CaNSC) and causes a massive increase in cytosolic free Ca(2+) concentration ([Ca(2+)](i)). This is followed by the opening ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2006
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00063.2006